Status:
RECRUITING
Cell Free DNA in Cardiac Sarcoidosis
Lead Sponsor:
Nabeel Hamzeh
Conditions:
Sarcoidosis With Myocarditis
Sarcoidosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventri...
Detailed Description
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Sarcoidosis results from an immune reaction to an environmental exposure...
Eligibility Criteria
Inclusion
- Sarcoidosis patients without evidence of active myocarditis:
- Inclusion:
- Diagnosis of sarcoidosis based on the ATS/ERS criteria.
- Normal 12 lead ECG within the past one year.
- Non-smoker.
- No immunosuppressive therapy for at least one year.
- Exclusion:
- Known cardiac disease.
- Active smoker.
- On immunosuppressive therapy.
- Sarcoidosis patients with evidence of active myocarditis:
- Inclusion:
- Diagnosis of sarcoidosis based on the ATS/ERS criteria.
- Evidence of active myocarditis based on recent cMRI or cFDG-PET.
- Non-smoker.
- Exclusion:
- Known cardiac disease other than sarcoidosis.
- Active smoker.
- On immunosuppressive therapy.
- Acute ST elevation myocardial infarction (STEMI):
- Inclusion:
- Diagnosis STEMI based on 1mm ST elevation in 2 or more contiguous leads.
- Symptom onset within 12 hours.
- Undergoing cardiac intervention for acute coronary syndrome.
- Able to consent for blood draw.
- Exclusion:
- Active smoker.
- Hemodynamically unstable.
- Healthy controls:
- Inclusion:
- No known cardiac disease.
- No known cardiovascular risk factors: hypertension, diabetes.
- Non-smoker.
Exclusion
Key Trial Info
Start Date :
May 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2028
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03858777
Start Date
May 1 2019
End Date
June 30 2028
Last Update
January 9 2026
Active Locations (2)
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1
University of Iowa
Iowa City, Iowa, United States, 52242
2
University of Iowa
Iowa City, Iowa, United States, 52242