Status:
UNKNOWN
Genetic Determinants of Kawasaki Disease
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Guy's and St Thomas' NHS Foundation Trust
University Hospitals Bristol and Weston NHS Foundation Trust
Conditions:
Kawasaki Disease
Atypical Kawasaki Disease
Eligibility:
All Genders
Brief Summary
Kawasaki disease (KD) is an acute self-limited vasculitis of infancy and early childhood. Most patients recover without sequelae although the inflammatory process causes permanent damage to the corona...
Detailed Description
The problem to be addressed; Kawasaki disease is now the most common cause of acquired heart disease in children in Japan and North America. Kawasaki disease arises when genetically predisposed child...
Eligibility Criteria
Inclusion
- Affected children will be recruited if the treating clinician has made a diagnosis of possible Kawasaki disease (even if they do not fulfil the criteria below for Kawasaki disease).
- The current standard diagnostic criteria for KD (Circulation 2001 103 335-336 doi: 10.1161/01.CIR 103.2.335) are:
- The presence of fever for at least five days plus four of the following criteria:
- Changes in the peripheral extremities Acute: erythema and oedema of hands and feet Convalescent: membranous desquamation of fingertips
- Polymorphous exanthema
- Bilateral painless bulbar conjunctival injection without exudate
- Changes in lips and oral cavity: erythema and cracking of lips, strawberry tongue, diffuse injection of oral and pharyngeal mucosae
- Cervical lymphadenopathy (\>1.5cm diameter), usually unilateral Patients meeting not all of these criteria may meet the criteria for atypical Kawasaki disease, ie. if they have fever and two or three of the above criteria and elevation of CRP or echocardiographic evidence of coronary artery dilatation.
- Parents of affected child must be biological parents.
Exclusion
- children who do not have a diagnosis of possible Kawasaki disease
Key Trial Info
Start Date :
February 25 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 30 2022
Estimated Enrollment :
1379 Patients enrolled
Trial Details
Trial ID
NCT03861130
Start Date
February 25 2013
End Date
December 30 2022
Last Update
November 17 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Imperial College London
London, United Kingdom, W2 1PG