Status:
UNKNOWN
A Study to Evaluate the Feasibility of Screening Relatives of Patients Affected by Non-Syndromic Thoracic Aortic Diseases
Lead Sponsor:
University of Leicester
Conditions:
Screening
Aortic Aneurysm and Dissection
Eligibility:
All Genders
16+ years
Phase:
NA
Brief Summary
The primary hypothesis is that a tailored programme of genetic and imaging screening of first- and second-degree relatives of patients affected by non-syndromic forms of thoracic aortic diseases will ...
Detailed Description
Diseases involving the thoracic aorta (the major artery in the body) are a major health problem affecting an increasing number of people worldwide. In particular, a group of these conditions termed N...
Eligibility Criteria
Inclusion
- NS-TAD probands operated on (n=16).
- FDR and SDR, aged 16 and above:
- At least two relatives willing to participate in the screening programme.
- Relatives able to understand English.
Exclusion
- Probands with syndromic aortopathies, including Marfan Syndrome, Loeys-Dietz Syndrome, Ehlers-Danlos Syndrome, Shprintzen-Goldberg syndrome, aneurysm-osteoarthritis syndrome, arterial tortuosity syndrome, and cutis laxa syndrome.
- Probands with aortic lesions associated with trauma and infections.
- Probands/relatives unable to give informed consent
Key Trial Info
Start Date :
March 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 20 2022
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT03861741
Start Date
March 1 2019
End Date
May 20 2022
Last Update
May 3 2021
Active Locations (1)
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1
Department of Cardiovascular Sciences
Leicester, Leicestershire, United Kingdom, LE3 9QP