Status:
UNKNOWN
Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.
Lead Sponsor:
University of Valencia
Collaborating Sponsors:
Centro Superior de Investigación en Salud Publica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Conditions:
Chronic Periodontitis
Periodontal Bone Loss
Eligibility:
All Genders
40-70 years
Phase:
PHASE4
Brief Summary
The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.
Detailed Description
Periodontitis in a chronic disease caused by bacteria present in the subgingival flora, which induces an inflammatory response of periodontal tissues. It has been suggested that some periodontal patho...
Eligibility Criteria
Inclusion
- Subjects of 40-70 years.
- No smokers or smokers of less than 10 cigarettes a day.
- Patients with periodontitis stages III and IV grades A-B.
- Presence of 20 natural teeth, including at least three molar teeth.
- Presence of at least 4 sites with at least 6 mm probing depth.
- Good general health
Exclusion
- Smokers of more than 10 cigarettes a day.
- Patients who have received periodontal treatment in the previous 12 months.
- Patients who have used antibiotics in the last 6 months.
- Routine use of oral antiseptics and / or during the previous 3 months.
- Systemic conditions that required antibiotic premedication.
- Women pregnant or nursing.
- Medications that could influence the outcome of periodontal therapy.
- Any known allergies to the test antimicrobial agents.
- Diabetics.
Key Trial Info
Start Date :
February 8 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2019
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03863249
Start Date
February 8 2019
End Date
August 1 2019
Last Update
March 5 2019
Active Locations (1)
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1
Marta Reglero Santaolaya
Valencia, Spain, 46010