Status:
UNKNOWN
Exploring Diuretics Effective Management in Acute Decompensated Heart Failure, EDEMA Trial
Lead Sponsor:
Cairo University
Collaborating Sponsors:
Kasr El Aini Hospital
Conditions:
Acute Decompensated Heart Failure
Diuretics Resistance
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
1. Evaluate efficacy and safety of continuous infusion of IV Frusemide compared to IV shots in acute decompensated heart failure ADHF 2. Evaluate superiority of time-adjusted metolazone to morning fru...
Detailed Description
After admission for acute decompensated heart failure and ensuring eligibility to participate in the study, accepting patients will be randomized by a pre-prepared tables into 2 equal groups (A = shot...
Eligibility Criteria
Inclusion
- Age more than 18 years.
- Chronic heart failure prior diagnosis, based on signs and or symptoms of heart failure, presenting with acute decompensation as judged by the physician to require hospitalization for IV diuretics
Exclusion
- Refusal to participate in the study.
- Allergy to IV frusemide.
- Severe renal impairment defined as eGFR\<30ml/m.
- Cardiogenic shock or hemodynamic instability judged by the treating physician to be unsuitable to participate.
Key Trial Info
Start Date :
March 31 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2021
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT03863626
Start Date
March 31 2019
End Date
December 1 2021
Last Update
January 27 2021
Active Locations (1)
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1
Faculty of Medicine, Cairo University Hospitals
Cairo, Egypt