Status:
UNKNOWN
Post-op Ketamine Study
Lead Sponsor:
Rothman Institute Orthopaedics
Conditions:
Osteo Arthritis Knee
Phase:
NA
Brief Summary
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. We hypo...
Eligibility Criteria
Inclusion
- 18 - 85 years of age
- ASA I - IV
- Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia
Exclusion
- BMI over 40\*
- Contraindication or allergy to opioid pain medication or ketamine\*
- Daily opioid use for pain control before surgery in excess of systemic morphine equivalent to 10 mg\*
- Ejection fraction (EF) less than 30%
- Creatinine clearance less than 30 mL/min\*
- History of chronic liver failure
- Desire for nerve block or general anesthesia
- Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic stress disorder, schizophrenia)
- Prior surgery on ipsilateral knee within the last 6 months
- Alcohol abuse
Key Trial Info
Start Date :
March 28 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 27 2019
Estimated Enrollment :
75 Patients enrolled
Trial Details
Trial ID
NCT03865550
Start Date
March 28 2016
End Date
April 27 2019
Last Update
March 7 2019
Active Locations (1)
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1
Rothman Institute
Philadelphia, Pennsylvania, United States, 19107