Status:
COMPLETED
Characterizing the Electroencephalogram Signature of Fentanyl During Induction of General Anesthesia
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Anesthesia
Eligibility:
All Genders
18-65 years
Brief Summary
While historically anesthesiologists rely on pharmacokinetics to track the loss of consciousness, new research in anesthesiology has identified the salient features of the electroencephalogram (EEG) t...
Detailed Description
Fentanyl is one of the most commonly used opioid analgesic drugs. Prior to induction of general anesthesia, fentanyl is frequently administered to blunt the nociceptive response to intubation. A typic...
Eligibility Criteria
Inclusion
- Undergoing surgery anticipated to take 2 hours or longer
Exclusion
- Craniofacial abnormalities
- Allergies to fentanyl, bisulfite, eggs or egg products, latex, soybeans, soybean oil BMI ≤ 30 (kg/m2)
- Known or suspected difficult intubation
- Known or suspected need for rapid sequence induction and intubation
- History of obstructive sleep apnea requiring CPAP
- History of uncontrolled gastroesophageal reflux disease (GERD)
- Opiate use within 24 hours
- History of opiate abuse within 3 years
Key Trial Info
Start Date :
June 27 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 30 2022
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT03866278
Start Date
June 27 2018
End Date
August 30 2022
Last Update
December 18 2023
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114