Status:
TERMINATED
NAFLD Among Patients With Chronic Kidney Disease and the Effect of Kidney Transplantation
Lead Sponsor:
Rigshospitalet, Denmark
Collaborating Sponsors:
Steno Diabetes Center Copenhagen
Herlev and Gentofte Hospital
Conditions:
Non-Alcoholic Fatty Liver Disease
Chronic Kidney Diseases
Eligibility:
All Genders
18-90 years
Brief Summary
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries affecting approximately 30 % of the general adult population. It represents an importa...
Detailed Description
INTRODUCTION Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in developed countries affecting approximately 30 % of the general adult population. The diseas...
Eligibility Criteria
Inclusion
- Inclusion Criteria (kidney transplanted patients):
- Outpatient at the department of nephrology at either Rigshospitalet or Herlev Hospital scheduled for a kidney transplantation with a living donor
- Impaired glucose tolerance: fasting glucose concentration \< 7,0 mmol/ l and a 2-hour glucose load ≥ 7,8 mmol/ l and \< 11,1 mmol/ l OR Impaired fasting glycaemia: Fasting blood glucose ≥ 6,1 mmol/ l and \< 7,0 mmol/ l and a 2-hour glucose load \< 7,8 mmol/ l OR Normal glucose tolerance: fasting glucose concentration \< 6,1 mmol/ l and a 2-hour glucose load \< 7,8 mmol/ l.
- Inclusion criteria (control group):
- Normal kidney function
- Normal glucose tolerance
- Exclusion Criteria:
- End stage liver disease as diagnosed by MELD (model for end stage liver disease) criteria OR
- At the waiting list for liver transplantation OR
- Daily alcohol intake above 20 g and 30 g for women and men respectively OR
- Known hepatitis A, B or C or hepatocellular carcinoma or other known liver disease OR
- Pregnancy OR
- Weight \> 130 kg OR
- Implanted pacemaker
Exclusion
Key Trial Info
Start Date :
May 29 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2022
Estimated Enrollment :
3 Patients enrolled
Trial Details
Trial ID
NCT03866421
Start Date
May 29 2019
End Date
March 31 2022
Last Update
May 2 2022
Active Locations (1)
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1
Department of Nephrology
Copenhagen, Denmark, 2100