Status:
UNKNOWN
Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes
Lead Sponsor:
University Hospital, Toulouse
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Thalamic Infarction
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
The aim is to expand evidence about the importance of the mediodorsal nucleus of the thalamus as a key node in human higher-order cognitive functions such as learning, decision-making, and adaptive be...
Detailed Description
The recruitment of patients with isolated thalamic lesion after stroke is known to be a challenge that the investigators overcame through the expertise of neurologists within their stroke unit. First...
Eligibility Criteria
Inclusion
- Inclusion criteria for patients:
- French as their mother tongue
- Absence of cognitive deterioration before the stroke.
- Visual, auditory (equipment authorized) and oral or written skills sufficient for the proper assessment using neuropsychological tests.
- First infarct affecting the thalamus.
- At least seven years' schooling from primary school
- Signed informed consent
- Chronic lesion (\> 3 months)
- Inclusion criteria for controls:
- French as their mother tongue
- Absence of cognitive complain
- Visual, auditory (equipment authorized) and oral or written skills sufficient for the proper assessment using neuropsychological tests.
- At least seven years of school from primary school
- Signed informed consent
- Exclusion criteria for patients:
- Neurological deficit or significant residual disability at inclusion.
- Aphasia, agnosia, apraxia or severe neglect, as demonstrated by clinical examination and neuropsychological tests.
- Subjects with a contraindication to MRI.
- General, neurological or psychiatric progressive disease.
- Exclusion criteria for controls:
- Subjects with a contraindication to MRI.
- General, neurological or psychiatric progressive disease.
Exclusion
Key Trial Info
Start Date :
May 14 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2023
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03867149
Start Date
May 14 2019
End Date
April 1 2023
Last Update
January 14 2020
Active Locations (1)
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1
Hopital Purpan - CHU de Toulouse
Toulouse, France, 31059