Status:
COMPLETED
Study to Evaluate the Bioequivalence of Pfizer Korea Inc. "XELJANZ 5Mg Tablet" in Healthy Volunteers
Lead Sponsor:
Chong Kun Dang Pharmaceutical
Conditions:
Rheumatoid Arthritis
Eligibility:
All Genders
19+ years
Phase:
PHASE1
Brief Summary
This study is an open-label, randomized, fasted, single dose, crossover study to evaluate the bioequivalence of Chong Kun Dang Pharmaceutical "Chong Kun Dang Tofacitinib Tablet" and Pfizer Korea Inc. ...
Detailed Description
To healthy subjects of forty (40), following treatments are administered dosing in each period and wash-out period is a minimum of 1 week. Reference drug: XELJANZ 5Mg Tablet / Test drug: Chong Kun Da...
Eligibility Criteria
Inclusion
- Healthy subject older than 19 years at the screening
- Individuals who had 18 kg/m2 ≤ Body Mass Index(BMI) ≤ 30kg/m2
- \* BMI = Weight(kg)/ Height(m)2
- Individuals without congenital/chronic diseases and without abnormal symptoms or diagnosis based on a medical examination(if necessary, EEG, ECG, chest X-ray, endoscope or upper gastrointestinal radiography)
- Individuals who were deemed to be appropriate as study subjects in accordance with the screening results (laboratory tests, ECG, chest X-ray etc.)
- Women who are not pregnant at physical examination
Exclusion
- Individuals who had enrolled to barbiturate's drugs by induction and inhibition of drug-metabolizing enzymes of drugs, such as drugs or excessive drinking within the 1 month
- Individuals who had taken any medication within 10 days prior to the first day of dosing
- Individuals who were deemed to be inappropriate to participate in the study by the investigator
- Individuals who had participated of other clinical study or bioequivalence study within the 3 months prior to the first day of dosing
- Individuals who donated whole blood within the 2 months, or blood components within 2 weeks prior to the first dose of the investigational product(s)
- Individuals who do not agree to the approved methods of double contraception and using spermicide for up to 7 days (only, 4 weeks for women who may be pregnant) after investigational product(s) administration (Double contraception: two or more of the use of condoms, intrauterine contraception, diaphragm, cervical cap, or a sexual partner who had been medically diagnosed infertility)
- Individuals with hypersensitivity to ingredients used in the investigational product(s)
- Patients with serious infection (e.g., Sepsis) or active infection including localized infection
- Patients with active tuberculosis
- Patients with severe hepatopathy
- Patients with an absolute neutrophil count (ANC) less than 500 cells/mm3
- Patients with an absolute lymphocyte count (ALC) less than 500 cells/mm3
- Patients who have hemoglobin levels less than 8 g/dL
- Women who are pregnant or may be pregnant or lactating
- Patients with hereditary diseases of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption etc.
- Patients with nephropathy (BUN\<8 or BUN\>20 or Creatinine\>1.5)
Key Trial Info
Start Date :
February 22 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 20 2019
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03868072
Start Date
February 22 2019
End Date
April 20 2019
Last Update
January 30 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Bestian Hospital
Osŏng, South Korea