Status:
COMPLETED
Effect of Intermittent Theta Burst Stimulation (iTBS) for Alleviating Symptoms of Schizophrenia Patients
Lead Sponsor:
WANG KAI
Conditions:
Schizophrenia
Functional Magnetic Resonance Imaging
Eligibility:
All Genders
18-52 years
Phase:
NA
Brief Summary
To investigate the treatment effect of intermittent theta-burst transcranial magnetic stimulation on symptomatic relief of schizophrenia patients, and the underlying neural mechanism by functional MRI...
Detailed Description
All patients underwent a medical evaluation that included physical examination and routine laboratory studies before and after intermittent theta-burst transcranial magnetic stimulation (iTBS) treatme...
Eligibility Criteria
Inclusion
- Patients met diagnostic criteria for schizophrenia or schizoaffective disorder using the Structural Clinical Interview for Diagnostic and Statistical Manual Diploma in Social Medicine (DSM)-IV (SCID, Version 2.0).
- Patients remain their psychotropic medication at steady dosages for at least 4 weeks prior to study entry and for the duration of the trial.
- Verbal intelligence quotient \> 85 as measured by using a Chinese version of the National Adult Reading Test.
Exclusion
- History of significant head trauma or neurological disorders
- Alcohol or drug abuse Focal brain lesions on T1- or T2-weighted fluid-attenuated inversion-recovery magnetic resonance images
- a prior history of a seizure not induced by drug withdrawal,first degree relative with epilepsy, significant neurological illness or head trauma, endocrine disease, such as thyroid disease, significant unstable medical condition, recent aggression or other forms of behavioral dyscontrol
- left-handedness, pregnancy
- estimated intelligence quotient\<80
- current alcohol or drug abuse
- inability to provide informed consent.
- Hamilton Anxiety Rating Scale or the Hamilton Depression Rating Scale score \> 14
Key Trial Info
Start Date :
May 21 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03868358
Start Date
May 21 2017
End Date
March 30 2021
Last Update
April 15 2021
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032