Status:
RECRUITING
Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy Subjects
Lead Sponsor:
Medical University of Vienna
Conditions:
Glaucoma, Open-Angle
Normal Tension Glaucoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Glaucoma is characterized by a progressive loss of retinal ganglion cells (RGCs) leading to optic nerve head (ONH) damage and associated visual field defects. The main risk factor for glaucoma is elev...
Eligibility Criteria
Inclusion
- Inclusion criteria
- Patients with primary open angle glaucoma
- Diagnosis of manifest primary open angle glaucoma defined as pathological optic disc appearance
- Glaucoma hemifield test outside normal limits
- Untreated IOP ≥ 21 mmHg on at least three measurements in the medical history
- Mean deviation in the visual field test is less than or equal 10dB (for one group) OR more than 10dB (for the other group)
- Patients with normal tension glaucoma
- Diagnosis of manifest normal tension glaucoma defined as pathological optic disc appearance
- Glaucoma hemifield test outside normal limits
- No evidence of untreated IOP \> 20 mmHg in the medical history
- Mean deviation in the visual field is less than or equal 10dB (for one group) OR more than 10dB (for the other group)
- Patients with ocular hypertension
- Normal ophthalmic findings except presence of ocular hypertension defined as untreated IOP ≥ 21 mmHg on at least three measurements in the medical history
- No signs of glaucomatous damage in the optic disc
- or the glaucoma hemifield test
- Healthy control subjects
- Normal ophthalmic findings
- IOP \< 20 mmHg on least three measurements
- No evidence of increased IOP in the medical history
- No signs of glaucomatous damage in the optic disc
- or the glaucoma hemifield test
- Exclusion criteria
- History of a severe medical condition as judged by the clinical investigator
- Abuse of alcoholic beverages
- Smoker
- Participation in a clinical trial in the 3 weeks preceding the study
- Exfoliation glaucoma, pigmentary glaucoma, history of acute angle closure
- Intraocular surgery within the last 6 months
- Ocular inflammation or infection within the last 3 months
- History of epilepsia
- Diabetes mellitus
- Untreated hypertension with systolic blood pressure \> 160 mmHg, diastolic blood pressure \> 95 mmHg
- Pregnancy
- Planned pregnancy or lactating
Exclusion
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03870230
Start Date
December 1 2017
End Date
March 1 2026
Last Update
May 23 2025
Active Locations (1)
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1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria