Status:
TERMINATED
The Effect of PC945 on Aspergillus Fumigatus Lung Infection in Patients With Cystic Fibrosis
Lead Sponsor:
Pulmocide Ltd
Conditions:
Aspergillosis
Cystic Fibrosis
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study tests the effects of an experimental drug PC945 in people with cystic fibrosis whose lungs are infected by the fungus Aspergillus fumigatus. PC945 may be useful in treating patients infect...
Eligibility Criteria
Inclusion
- Subject must be male or female, aged 18 years inclusive or older (at the time of consent).
- Subject must be willing and able to adhere to the restrictions and prohibitions required by this protocol.
- Each subject must sign an informed consent form (ICF) indicating that he or she understands the purpose and requirements of the study and that they are willing to participate.
- A confirmed diagnosis of CF by standard criteria.
- Subject is able to produce sputum.
- A history of persistently positive A. fumigatus sputum cultures from at least 2 sputum samples in the last year, the most recent of which must have been within the last 6 months.
- Subject must have a positive sputum fungal culture at screening with one or more colonies of A. fumigatus detected using a modified standard approach.
Exclusion
- Any other disease or condition, which in the Investigator's medical opinion would preclude the subject's participation in a clinical trial.
- Is taking inhaled amphotericin B or has taken it within 7 weeks of Day 1.
- Is taking systemic steroid treatment or has taken it within 4 weeks of Day 1. Subjects considered to be stable on a systemic steroid dose of \<15 mg for at least a month will not be excluded.
- Is taking systemic antifungal treatment (intravenous, oral or inhaled) or has received antifungal therapy (intravenous, oral or inhaled) within 6 weeks of Day 1.
- If female, the subject is pregnant (e.g., has a positive serum β human chorionic gonadotropin (β-hCG) at screening or a positive urinary pregnancy test pre-dose on Day 1), lactating or breast feeding.
- Any respiratory exacerbation within 2 weeks of the start of the study.
- Any upper respiratory tract infection or signs or symptoms thereof within 2 weeks prior to dosing.
- Positive culture for Mycobacterium abscessus within 12 months before screening or between screening and baseline, or currently receiving treatment for Mycobacterium abscessus.
- Has chronic, active hepatitis or a positive hepatitis B surface antigen or positive hepatitis C antibody result at screening.
- Is taking antiretroviral protease inhibitor therapy.
- Allergy to any of the active or inactive ingredients in the study medication.
- History of drug (or other) allergy or intolerance that, in the opinion of the Investigator or Pulmocide Medical Monitor, would contraindicate their participation.
- Clinically significant haemoptysis (\>200 mL per episode) within 90 days before screening.
- Subject is mentally or legally incapacitated. 19 July 2018 CONFIDENTIAL Page 27 of 58 Pulmocide Ltd Clinical Protocol PC\_ASP\_003
- Subject is employed or is a first-degree relative of anyone employed by Pulmocide, a participating clinical trial site, or any contract research organisation involved in the study.
- Any other reason that the Investigator considers makes the subject unsuitable to participate.
Key Trial Info
Start Date :
April 3 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2020
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT03870841
Start Date
April 3 2019
End Date
June 1 2020
Last Update
July 16 2021
Active Locations (2)
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1
Royal Brompton Hospital
London, United Kingdom, SW3 6NP
2
Northwest Lung Research Centre
Manchester, United Kingdom, M23 9LT