Status:
UNKNOWN
Paced Electrogram Feature Analysis (PEFA) for Ablation Targeting in Ischaemic Ventricular Tachycardia
Lead Sponsor:
Dr. Damian Redfearn
Conditions:
Ischemic Ventricular Tachycardia (VT)
Eligibility:
All Genders
19+ years
Phase:
NA
Brief Summary
Canadian multicentre prospective cohort study of 40 patients with ischaemic heart disease and therapy from an implantable cardioverter defibrillator (ICD).
Detailed Description
Paced Electrogram Feature Analysis is employed to elucidate VT isthmus sites and target Type I sites for ablation to prevent recurrent VT/VF. The trial hypothesis is: catheter ablation employing PEFA...
Eligibility Criteria
Inclusion
- greater than 18 years of age
- Ischaemic heart disease and prior myocardial infarction (using the international definition of MI: Q waves or imaging evidence of regional myocardial akinesis/thinning in the absence of a non-ischemic cause with documentation of prior ischaemic injury)
- Eligible for catheter ablation as standard of care
- Implantable Cardioverter Defibrillator
Exclusion
- Unable or unwilling to provide consent
- Both mechanical aortic and mitral valve
- LV thrombus,
- NYHA class IV heart failure symptoms
- Contraindication to heparin
- Survival limited to \<1 year in estimation of attending care team,
- Prior VT ablation Exclusion to standard of care VT catheter ablation procedure such as
- Active ischaemia (acute thrombus diagnosed by coronary angiography, or dynamic ST segment changes demonstrated on ECG) or another reversible cause of VT (e.g. drug- induced arrhythmia), had recent acute coronary syndrome within 30 days thought to be due to acute coronary arterial thrombosis, or have CCS functional class IV angina. Note that biomarker level elevation alone after ventricular arrhythmias does not denote acute coronary syndrome or active ischemia.
- Non-ischaemic cardiomyopathy because of reduced ablation success and PEFA has not been examined in the context of a non-ischaemic cardiomyopathy
Key Trial Info
Start Date :
August 13 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03870854
Start Date
August 13 2019
End Date
September 30 2025
Last Update
November 15 2023
Active Locations (3)
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1
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
2
London Health Sciences Centre
London, Ontario, Canada, N6A 5A5
3
University of Ottawa Heart Institutation
Ottawa, Ontario, Canada