Status:
UNKNOWN
Neoantigen-primed DC Vaccines Therapy for Refractory Lung Cancer
Lead Sponsor:
Shenzhen People's Hospital
Conditions:
Carcinoma, Non-Small Cell Lung
Carcinoma, Small Cell Lung
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
Various of immunotherapies are now widely applied in the treatment of lung cancer. Neoantigens arising from the mutations of the tumor genome expressed specifically on the tumor cell instead of normal...
Detailed Description
Cancer genome research has exploded benefits from the application of modern high-throughput genome sequencing in the past few years. Since usually there are no common antigens expressed on the surface...
Eligibility Criteria
Inclusion
- Age ≥18 years ≤ 70 years at the time of informed consent
- Signed informed consent to be provided
- pathologically confirmed lung cancer
- failed in previous standard chemotherapy and targeted therapy
- Life expectancy not less than 90 days
- Karnofsky performance status 0-1
- adequate organ functions
Exclusion
- Actively infectious condition including hepatitis
- Women of child-bearing potential who are pregnant or breastfeeding because of the potentially dangerous effects of the treatment on the fetus or infant.
- Any form of primary immunodeficiency (such as Severe Combined Immunodeficiency Disease).
- Concurrent opportunistic infections (The experimental treatment being evaluated in this protocol depends on an intact immune system. Patients who have decreased immune competence may be less responsive to the experimental treatment and more susceptible to its toxicities).
- Active systemic infections, coagulation disorders or any other active major medical illnesses.
- Patients who are receiving any other investigational agents.
Key Trial Info
Start Date :
April 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03871205
Start Date
April 1 2019
End Date
December 30 2020
Last Update
March 12 2019
Active Locations (1)
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1
Shenzhen People's Hospital
Shenzhen, Guangdong, China, 518020