Status:
COMPLETED
Umbilical Cord Blood Transfusion in Progeria Syndrome
Lead Sponsor:
Bundang CHA Hospital
Conditions:
Hutchinson-Gilford Progeria Syndrome
Eligibility:
All Genders
Phase:
PHASE1
PHASE2
Brief Summary
This is a pilot study on safety and efficacy of umbilical cord blood therapy for patients with Hutchinson Gilford Progeria syndrome (HGPS). This is an 1 year trial with 3 IV infusions (4 months apart ...
Detailed Description
This is a pilot study on safety and efficacy of umbilical cord blood therapy for patients with Hutchinson Gilford Progeria syndrome (HGPS). HGPS is a rare genetic disease where affected LMNA gene codi...
Eligibility Criteria
Inclusion
- This is a pilot study including 2 patients with HGPS.
- those who were clinically and genetically diagnosed as Hutchinson-Gilford progeria syndrome
Exclusion
- those who show definite hemorrhage or ischemia on brain MRI
- those who are affected with systemic infection during study enrolling period
- those who are not able to able to make consents to the study; those who are not accompanying any guardians
- those who were enrolled in other clinical trials within last 30 days
- those who are not appropriate according to laboratory criteria
- whose ALT/AST \> 2 fold of normal limit
- whose serum creatinine \> 1.5 fold of normal limit
- whose total bilirubin \> 2 fold of normal limit
- whose total WBC count \< 3000/mm3
- whose platelet count \< normal lower limit
- those who are diagnosed with other malignancies
- those who are affected by other serious medical (cardiopulmonary, gastrointestinal, endocrinologic, etc.) conditions
Key Trial Info
Start Date :
March 5 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2020
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT03871972
Start Date
March 5 2019
End Date
June 1 2020
Last Update
November 4 2020
Active Locations (1)
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1
Bundang CHA Medical Center
Seongnam-si, Gyeonggi-do, South Korea, 13496