Status:
COMPLETED
Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock
Lead Sponsor:
Northern Jiangsu People's Hospital
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine whether the combination therapy (vitamin C,thiamine and hydrocortisone) is effective in the treatment of septic shock.
Detailed Description
Septic Shock is a leading cause of morbidity and mortality in critically ill patients worldwide. A potential benefit of vitamin C with thiamine and low-dose hydrocortisone in the treatment of septic ...
Eligibility Criteria
Inclusion
- Age 18 years old or older
- Onset of septic shock within 12 hours
Exclusion
- Systemic corticosteroid therapy within the last 3 months before septic shock
- High-dose steroid therapy
- Immunosuppression
- Pregnant
- Known glucose-6 phosphate dehydrogenase (G-6PD) deficiency
- Known hemachromatosis
- Known allergy to vitamin C, hydrocortisone, or thiamine
- Anticipated death from a preexisting disease within 90 days after randomization (as determined by the enrolling physician)
- Refusal of the attending staff or patient family
Key Trial Info
Start Date :
February 19 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 20 2021
Estimated Enrollment :
408 Patients enrolled
Trial Details
Trial ID
NCT03872011
Start Date
February 19 2019
End Date
September 20 2021
Last Update
September 23 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Northern Jiangsu Province people's hospital
Yangzhou, Jiangsu, China, 225000