Status:
COMPLETED
Parathyroid Hormone Kinetics During CRRT
Lead Sponsor:
Uniwersytecki Szpital Kliniczny w Opolu
Conditions:
Critical Illness
Multi Organ Failure
Eligibility:
All Genders
18+ years
Brief Summary
The objective of this study is to assess the parathyroid hormone serum concentrations and kinetics in critically ill patients admitted to the intensive care unit due to multi-organ failure and undergo...
Eligibility Criteria
Inclusion
- Acute respiratory failure
- Acute circulatory failure
- acute kidney injury treated with regional citrate anticoagulation continuous renal replacement therapy by means of continuous veno-venous hemodiafiltration (CVVHDF
- continuous renal replacement therapy started no later than 48 hours after admission
- SOFA score 5 or more
Exclusion
- age less than 18 years
- acute liver failure
- hypercalcemia at admission (total calcium plasma level \> 10.6 mg/dL; total ionized calcium plasma level \> 1.35 mmol/L
- parathyroid glands disease
- end stage renal disease
- therapeutic plasma exchange
- extracorporeal membrane oxygenation
- unfavorable outcome (death) predicted within 72 hours (as assessed by investigator)
- lack of relatives consent
Key Trial Info
Start Date :
May 6 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03873675
Start Date
May 6 2019
End Date
November 1 2020
Last Update
January 14 2022
Active Locations (3)
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1
Department of Endocrinology, Diabetology and Isotope Therapy, Wroclaw Medical University, Poland.
Wroclaw, Lower Silesian Voivodeship, Poland, 50-367
2
Department of Endocrinology, Szpital Wojewodzki w Opolu
Opole, Silesian Voivodeship, Poland, 45-372
3
Department of Anesthesiology and Intensive Care, Uniwersytecki Szpital Kliniczny w Opolu
Opole, Silesian Voivodeship, Poland, 45-401