Status:
COMPLETED
Vitamin D in Periodontal and Cardiovascular Disease Progression
Lead Sponsor:
University of Messina
Conditions:
Vitamin D Deficiency
Eligibility:
All Genders
25-70 years
Brief Summary
Vitamin D has been considered to possess anti-inflammatory and antimicrobial activity which may be a link for the known interaction of periodontitis (CP) and coronary heart disease (CHD). This study i...
Detailed Description
Using a cross-sectional design, a total of 39 patients with CP, 38 patients with CHD, 38 patients with both CP and CHD, and 37 healthy subjects will enrolled in the present study.
Eligibility Criteria
Inclusion
- Presence of at least twenty teeth
- CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm;
- Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Key Trial Info
Start Date :
January 2 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 5 2019
Estimated Enrollment :
179 Patients enrolled
Trial Details
Trial ID
NCT03873935
Start Date
January 2 2015
End Date
February 5 2019
Last Update
December 8 2022
Active Locations (1)
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1
University of Messina
Messina, Italy, 98125