Status:
COMPLETED
Evaluation of Arginine in Periodontal and Cardiovascular Disease
Lead Sponsor:
University of Messina
Conditions:
Metabolic Disorder
Arginine; Hyperaminoaciduria
Eligibility:
All Genders
19-75 years
Brief Summary
Asymmetric dimethylarginine (ADMA) plays a key role in endothelial function and may be a link for the known interaction of periodontitis and coronary heart disease (CHD). The investigators compared th...
Detailed Description
The aim of this study was to evaluate a possible association between both saliva and serum ADMA levels in patients with CP and with CHD and if the serum ADMA levels are mediated by serum CRP.
Eligibility Criteria
Inclusion
- Presence of at least 16 teeth
- CP with a minimum of 40% of sites with a clinical attachment level (CAL) ≥2mm and probing depth (PD) ≥4mm;
- Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Key Trial Info
Start Date :
January 6 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2019
Estimated Enrollment :
141 Patients enrolled
Trial Details
Trial ID
NCT03873948
Start Date
January 6 2014
End Date
March 1 2019
Last Update
October 4 2019
Active Locations (1)
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1
University of Messina
Messina, Italy, 98125