Status:
COMPLETED
Plasma TMAO and Choline Levels in Individuals With Metabolic Syndrome - Comparison Between Eggs and Choline Supplement.
Lead Sponsor:
University of Connecticut
Collaborating Sponsors:
American Egg Board
Conditions:
Coronary Artery Disease
Diabetes
Eligibility:
All Genders
35-70 years
Phase:
NA
Brief Summary
The objective of this study is to determine the effects of consuming either 3 eggs per day and compare it to daily choline supplement (choline bitartrate) for a dose of approximately 400 mg/day on pla...
Detailed Description
Epidemiological data suggests that egg intake does not increase the risk for cardiovascular disease (CVD). In fact eggs are a good source of phosphatidyl choline (PC) and choline has a number of metab...
Eligibility Criteria
Inclusion
- All genders
- 35-70 years
- Metabolic syndrome (based on 3 out of 5 characteristics: waist circumference \> 88 cm for women and \> 102 cm for men, plasma triglycerides \> 150 mg/dL, fasting glucose \> 100 mg/dL, blood pressure \> 135/85 and HDL \< 40 mg/dL for men and \< 50 mg/dL for women),
- willing to consume 3 eggs per day for 4 weeks
- willing to consume choline supplement (400 mg/day for 4 weeks)
Exclusion
- Self-reported diaberes, cardiovascular disease, history of stroke, liver disease or cancer
- Taking glucose lowering medications
- Taking antibiotics in the previous 1 month
- Triglycerides \> 500 mg/dL,
- Cholesterol \> 240 mg/dL,
- blood pressure \> 145/100 mm of Hg
- Allergic to eggs or to choline
Key Trial Info
Start Date :
November 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2020
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03877003
Start Date
November 1 2018
End Date
June 30 2020
Last Update
November 3 2020
Active Locations (2)
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1
Department of Nutritional Sciences
Storrs, Connecticut, United States, 06269
2
University of Connecticut
Storrs, Connecticut, United States, 06269