Status:
UNKNOWN
Expiratory Muscle Strength Training (EMST) in Neuromuscular Disorders
Lead Sponsor:
University of Calgary
Collaborating Sponsors:
Muscular Dystrophy Canada
Conditions:
Oculopharyngeal Muscular Dystrophy
Muscular Dystrophies
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the impact of expiratory muscle strength training (EMST) on the swallowing, breathing, oral intake, quality of life and cough function of people with oculop...
Detailed Description
Outline: Twenty participants with OPMD, with dysphagia, will be recruited from Neuromuscular clinics within Calgary. The investigators will enrol patients in a parallel group, sham-controlled, random...
Eligibility Criteria
Inclusion
- Diagnosis of oculopharyngeal muscular dystrophy (OPMD)
- 18 years of age or older
- Must be capable of providing informed consent
- Must be able to undergo respiratory function testing and swallowing studies
- Must have a forced vital capacity (FVC) greater than 60%
- A score of 3 or greater on the Eating Assessment Tool-10 (EAT-10; self-administered, symptom-specific outcome instrument for dysphagia. A score of 3 or greater indicates increased stress around eating)
- A score of 26 or greater on the Montreal Cognitive Assessment (MoCA; 30-point screening assessment used for detecting cognitive impairment. A score of 26 or greater is considered to be within functional limits.)
Exclusion
- Severe coronary artery disease
- Acute myocardial infarction
- Moderate to severe hypovolemia
- Acute neurological events
- Unstable cardiac status
- Recent hernia
- Severe chronic obstructive pulmonary disease (COPD)
- Uncontrolled reflux issues
- Women who are pregnant, or who suspect they may be pregnant
- Cognitive impairment that would prevent comprehension of instructions and adherence to intervention guidelines (a score of less than 26 points on the MoCA)
Key Trial Info
Start Date :
May 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT04009408
Start Date
May 1 2022
End Date
December 1 2022
Last Update
April 21 2022
Active Locations (1)
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1
Neuromuscular Clinic, South Health Campus
Calgary, Alberta, Canada, T3M 1M4