Status:
COMPLETED
Comparison of Probiotics, Metformin & Their Combination Therapy in the Treatment of PCOS
Lead Sponsor:
Ziauddin University
Conditions:
Polycystic Ovary Syndrome
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
Polycystic ovary syndrome (PCOS) is a common gynecological state worldwide characterized by numerous small cysts in the ovaries mainly due to the imbalance of endocrine hormones in premenopausal women...
Detailed Description
Polycystic ovary syndrome (PCOS) is a hormonal disorder affecting the women of reproductive age. It is a heterogeneous health condition that affects 1 in every 10 women of childbearing age. Women of a...
Eligibility Criteria
Inclusion
- The patient will be included according to the Rotterdam European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine sponsored a PCOS consensus criterion which says the presence of any two of the following three features must be present for the patient to be diagnosed as a case of PCOS:
- Oligomenorrhea and/or amenorrhea (Oligomenorrhea\>45 days or \<8 cycles per year and amenorrhea \>3 months in women with previous periodic menses) for a period of 6 months
- Clinical and/or biochemical hyperandrogenemia, the presence of acne, hirsutism (FG score\>8), and alopecia
- Polycystic ovaries on sonography (\>12 follicles in one or both ovaries, 2-9 mm in diameter and/or increased ovarian volume \>10 mL).
Exclusion
- History of chronic diseases
- Allergic to probiotic or metformin
- Current or previous (within the last 6 months) use of chemotherapy or other drugs.
- History of smoking
- Individuals with autoimmune disease
- Individuals with autoimmune disease.
Key Trial Info
Start Date :
December 6 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 28 2020
Estimated Enrollment :
78 Patients enrolled
Trial Details
Trial ID
NCT04009603
Start Date
December 6 2018
End Date
January 28 2020
Last Update
July 7 2020
Active Locations (1)
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1
Dr. Urooj
Karachi, Sindh, Pakistan, 75300