Status:
SUSPENDED
Controlled Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
Tobacco Related Disease Research Program
Conditions:
Pollution; Exposure
Smoke Inhalation
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
This study compares the health effects of dermal and inhalational exposure to thirdhand cigarette smoke to those of inhalational exposure to secondhand cigarette smoke in healthy, adult nonsmokers. Ou...
Detailed Description
Thirdhand cigarette smoke is the smoke chemicals that persist in the environment after smoking. Indoors, they can be found both on surfaces and in the air. Thirdhand smoke derives from secondhand smok...
Eligibility Criteria
Inclusion
- Healthy on the basis of medical history, blood pressure and test of C-reactive protein, lipids and blood sugar.
- Non-smoker not exposed to second-hand smoke (SHS) as determined by saliva cotinine \< 10 ng/ml and tetrahydrocannabinol (THC) \< 50 ng/ml.
- Flow mediated dilation of 4% or greater at screening visit.
Exclusion
- Age 18 \< or \> 50 Physician diagnosis of asthma, heart disease, hypertension, thyroid disease, diabetes, renal or liver impairment or glaucoma.
- Unstable psychiatric condition (such as current major depression, history of schizophrenia or bipolar disorder) or current use of more than two psychiatric medications Systolic blood pressure \> 150 Diastolic blood pressure \> 100 Blood glucose \> 110 LDL \>130 Pregnancy or breastfeeding (by urine Human Chorionic Gonadotropin (hCG) and/or history) Alcohol or illicit drug dependence within the past 5 years BMI \> 35 and \< 18 Current illicit drug use (by history or urine test) More than 1 pack year smoking history Ever a daily marijuana smoker Smoked anything within the last 3 months Unable to hold allergy or other over-the-counter (OTC) medicines Occupational exposure to smoke, dusts and fumes Concurrent participation in another clinical trial Unable to communicate in English No social security number
Key Trial Info
Start Date :
January 20 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2024
Estimated Enrollment :
66 Patients enrolled
Trial Details
Trial ID
NCT04013256
Start Date
January 20 2020
End Date
October 31 2024
Last Update
August 28 2023
Active Locations (1)
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1
Zuckerberg San Francisco General Hospital
San Francisco, California, United States, 94110