Status:
WITHDRAWN
Influence of Respiratory Mechanics on Brain-specific Monitoring in Brain-injured Patients
Lead Sponsor:
Piquilloud Imboden Lise
Conditions:
Brain Injuries
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Increase in intracranial pressure (ICP) could be associated with increase in positive end-expiratory pressure (PEEP) level. Data are however disparate and interactions between ventilation with high PE...
Eligibility Criteria
Inclusion
- Acute brain injury of any etiology requiring multimodal brain monitoring (intraparenchymal intracranial pressure, brain-tissue oxygen tension and cerebral microdialysis)
- Controlled mechanical ventilation via endotracheal tube
- Patient needing deep sedation
Exclusion
- pregnancy
- contraindications to nasogastric probe placement: basilar skull or significant naso-facial fractures, significant esophageal or gastric trauma or bleeding, previous esophageal surgery, significant bleeding diathesis (spontaneous aPTT \> 60 sec, PT \< 40%, INR \> 1.8, platelets \< 50000/mm3), known esophageal or gastric varices
- decompressive craniectomy
- intracranial pressure monitoring method other than intraparenchymal (e.g. connected to external ventricular drain)
- severe relevant physiological instability contraindicating an increase in PEEP: severe baseline intracranial pressure elevation (\> 20 mmHg), severe hemodynamic instability (defined as norepinephrine requirements \> 0.5 μg/kg/min or cardiogenic shock, defined as any use of dobutamine)
- conditions that interfere with accurate measurements of respiratory mechanics: bronchopleural fistula, pneumothorax.
- Withhold of life-sustaining therapy for medical reasons
Key Trial Info
Start Date :
August 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 2 2020
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04013698
Start Date
August 1 2019
End Date
November 2 2020
Last Update
June 11 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Lausanne University Hospitals
Lausanne, Canton of Vaud, Switzerland, 1011