Status:
UNKNOWN
Dextrose, Corticosteroids and Surgical Release in Carpal Tunnel Syndrome
Lead Sponsor:
University Medical Centre Ljubljana
Conditions:
Peripheral Nervous System Diseases
Nerve Compression Syndromes
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The objective of the present study is to compare the effectiveness of 5% dextrose, local corticosteroids injections and surgical release in patients with electrodiagnostically (EDx) mild to moderate c...
Detailed Description
Surgical release of the carpal ligament is a standard treatment of the median nerve entrapment at the wrist. Local corticosteroid injections are also an established alternative, particularly for EDx m...
Eligibility Criteria
Inclusion
- Inclusion Criteria (subject diagnosed as CTS if meeting criterion 1 + at least one of criteria 2 or 3):
- numbness and tingling in at least two out of the first four digits;
- symptoms exacerbated during the night or in the morning, on holding the objects or repetitive use of the hand;
- symptoms relieved by shaking the hand or reposition of the arm.
- In addition to these clinical criteria for recruitment EDx confirmation will also be needed. Only patients with bilateral EDx mild to moderate CTS will be included.
- Exclusion Criteria:
- polyneuropathy, symptoms of polyneuropathy, and all conditions causing polyneuropathy (e.g., diabetes);
- multiple mononeuropathy (e.g., hereditary neuropathy with liability to pressure palsies, syndrome Lewis Sumner);
- motor neuron disorders (e.g., monomelic amyotrophy, amyotrophic lateral sclerosis - ALS);
- brachial plexopathy;
- other focal neuropathies affecting upper limbs (e.g., other median neuropathies, ulnar neuropathies, thoracic outlet syndrome); or
- previous surgery or local injections for CTS.
Exclusion
Key Trial Info
Start Date :
March 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04014244
Start Date
March 1 2021
End Date
September 1 2023
Last Update
March 11 2021
Active Locations (1)
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1
University Medical Center Ljubljana, Department of Neurology, Institute of Clinical Neurophysiology
Ljubljana, Slovenia, 1000