Status:
RECRUITING
Safety and Efficacy of Fecal Microbiota Transplantation
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Crohn Disease
Ulcerative Colitis
Eligibility:
All Genders
Phase:
NA
Brief Summary
The gut microbiota is critical to health and functions with a level of complexity comparable to that of an organ system. Dysbiosis, or alterations of this gut microbiota ecology, have been implicated ...
Eligibility Criteria
Inclusion
- Confirmed diagnosis of any of the following diseases:
- Crohn's disease
- Ulcerative colitis
- Celiac disease
- Irritable bowel syndrome
- Functional dyspepsia
- Constipation
- Antibiotic-associated diarrhea or any antibiotic- associated complications/symptoms
- Metabolic syndrome such as diabetes mellitus and obesity
- Multidrug-resistant infection
- Hepatic encephalopathy
- Multiple sclerosis
- Pseudo-obstruction
- Carbapenem-resistant Enterobacteriaceae (CRE) or Vancomycin-resistant Enterococci (VRE) infection
- Multiple organ dysfunction
- Dysbiotic bowel syndrome
- MRSA enteritis
- Pseudomembranous enteritis
- Alopecia, autism
- Graft-versus-host disease
- Idiopathic thrombocytopenic purpura (ITP)
- Atopy or allergy
- Liver disease such as Nonalcoholic fatty liver disease (NAFLD) and Nonalcoholic steatohepatitis (NASH)
- Alcohol dependence
- Psoriatic arthropathy that has suboptimal control of disease despite standard treatment.
Exclusion
- Known contraindication to all FMT infusion method such as nasoduodenal tube insertion, oesophago-gastro-duodenoscopy (OGD), enteroscopy, colonoscopy and enema
- Any conditions that may render the efficacy of FMT or at the discretion of the investigators
- Current pregnancy
Key Trial Info
Start Date :
July 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 31 2030
Estimated Enrollment :
450 Patients enrolled
Trial Details
Trial ID
NCT04014413
Start Date
July 15 2019
End Date
October 31 2030
Last Update
August 22 2024
Active Locations (1)
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1
The Chinese University of Hong Kong
Hong Kong, Shatin, Hong Kong, 000000