Status:
COMPLETED
Mini Theta Burst TMS in MDD Patients
Lead Sponsor:
University of Pennsylvania
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
This is not a treatment study. In this study, the researchers are primarily interested in examining whether functional MRI (fMRI)-guided transcranial magnetic stimulation (TMS) may be more effective ...
Detailed Description
This study will involve a baseline Magnetic Resonance Imaging (MRI) scan, Transcranial Magnetic Stimulation (TMS), and TMS interleaved with functional MRI (fMRI) scans. After screening, eligible part...
Eligibility Criteria
Inclusion
- 18 to 60 years old, inclusive
- Right-handed
- Currently experiencing a major depressive episode (MDD)
- Capacity to give informed consent and follow study procedures
- Command of English language to understand/ respond to written and verbal instructions
Exclusion
- MRI contraindications (i.e., metal in body, claustrophobia, etc.)
- TMS contraindications (i.e., seizure disorder)
- Diagnosis of exclusionary psychiatric disorder (i.e., schizophrenia, bipolar)
- Current use of psychiatric medication and unable/ willing to safely withdraw
- Refusal to abstain from alcohol or drugs for duration of study
- Medication use that reduces seizure threshold
- Medication that interferes with blood flow (i.e., opioids, antihypertensive)
- Known neurological disorder or significant disability that interferes with study procedures
- Woman who is pregnant or breastfeeding
Key Trial Info
Start Date :
July 14 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2021
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT04014959
Start Date
July 14 2017
End Date
June 30 2021
Last Update
April 2 2024
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104