Status:
COMPLETED
Markers of Atherosclerosis in Overweight, Postmenopausal Women Following Daily Watermelon Consumption
Lead Sponsor:
Appalachian State University
Collaborating Sponsors:
National Watermelon Promotion Board; https://www.watermelon.org
Conditions:
Postmenopausal
Overweight and Obesity
Eligibility:
FEMALE
50-75 years
Phase:
NA
Brief Summary
The primary purpose of this study is to determine the effectiveness of six weeks of watermelon puree supplementation, compared to control (no treatment), on blood antioxidant capacity, inflammation ma...
Detailed Description
ORIENTATION AND PRE-STUDY TESTING (1-2 hours): 1. Come to the Lab in the morning in an overnight fasted state. 2. Complete orientation to the study, and provide voluntary consent to join the study. 3...
Eligibility Criteria
Inclusion
- Female
- 50 to 75 years of age,
- have not menstruated for at least 1 year (menopause),
- have a BMI of ≥25 kg/m2,
- nonsmoker with
- no diagnosed history of chronic diseases including: coronary heart disease, stroke, cancer, type 1 or 2 diabetes mellitus, or rheumatoid arthritis;
- may not regularly consume large quantities of L-citrulline/L-arginine rich foods (red meat, tuna fish, cheese, nuts),
- may not regularly take L-citrulline/L-arginine supplements,
- may not use anti-hypertension medications (including diuretic medications),
- may not use exogenous ovarian hormones, or
- may not use medications known to influence inflammation within the two weeks of the study period (specifically non-steroidal anti-inflammatory drugs; NSAIDS).
Exclusion
- Male,
- younger than 50 or older than 75 years of age,
- menstruated within the last year,
- have a BMI of \<25 kg/m2, smoker,
- diagnosed history of chronic diseases including: coronary heart disease, stroke, cancer, type 1 or 2 diabetes mellitus, or rheumatoid arthritis;
- regularly consume large quantities of L-citrulline/L-arginine rich foods (red meat, tuna fish, cheese, nuts),
- regularly take L-citrulline/L-arginine supplements,
- use anti-hypertension medications (including diuretic medications),
- use exogenous ovarian hormones, or
- use medications known to influence inflammation within the two weeks of the study period (specifically non-steroidal anti-inflammatory drugs; NSAIDS).
Key Trial Info
Start Date :
April 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT04015544
Start Date
April 1 2014
End Date
July 1 2014
Last Update
July 11 2019
Active Locations (1)
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1
Appalachian State University
Boone, North Carolina, United States, 28608