Status:
UNKNOWN
Probiotics Attenuate Postoperative Cognition Decline
Lead Sponsor:
RenJi Hospital
Conditions:
Necrosis of Femoral Head
Knee Osteoarthritis
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
The aim of this study was to evaluate whether perioperative probiotics can reduce the incidence of postoperative cognitive dysfunction and postoperative delirium.
Eligibility Criteria
Inclusion
- . Age is greater than or equal to 65 years old
- . Can communicate normally
- . Selective knee ankle, hip replacement or lumbar open reduction and internal fixation under general anesthesia
- . ASA graded at I-II level
- . Patient or family informed consent
Exclusion
- . Have a brain disease, or have a history of brain disease
- .MMSE check of less than 24 points.
- . History of neurological and psychological disorders including AD, stroke, psychosis
- . Serious hearing or visual impairment
- . Preoperative systolic blood pressure \>190mmhg, or diastolic blood pressure \>100mmhg
- . The patient or family refuses
Key Trial Info
Start Date :
December 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
220 Patients enrolled
Trial Details
Trial ID
NCT04017403
Start Date
December 15 2019
End Date
December 31 2023
Last Update
May 2 2022
Active Locations (3)
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1
Renji Hospital
Shanghai, Shanghai Municipality, China, 200127
2
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
Shanghai, Shanghai Municipality, China
3
Jin Cheng people's hospital
Jincheng, Shanxi, China