Status:
UNKNOWN
Circulating miRNAs and Bone Microstructure in Adults With Hypophosphatasia
Lead Sponsor:
Medical University of Vienna
Conditions:
Hypophosphatasia
Bone Diseases, Metabolic
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the study is to accomplish a complete bone status of patients with HPP using new approaches to assess bone quality.
Detailed Description
Hypophosphatasia (HPP) is a hereditary disease of bone metabolism that is not yet curable. Clinical phenotype is variable and reaches from demineralization of bone, deformation of the skeleton, micros...
Eligibility Criteria
Inclusion
- Inclusion Criteria for Hypophosphatasia (HPP)
- genetically verified hypophosphatasia
- age \>18 years
- written informed consent
- complete serological and radiological examinations
- Inclusion Criteria für Controls:
- healthy men and women without any history of musculoskeletal diseases
- written informed consent
- Alkaline phosphatase (AP) in reference range
- complete serological and radiological examinations
- Exclusion Criteria for both Groups:
- inflammatory diseases
- other genetic disorders affecting bone such as osteogenesis imperfecta, Ehlers-Danlos-syndrome and fibrous dysplasia
- diabetes mellitus type 1 and 2
- COPD
- chronic kidney and liver dysfunction
- systemic glucocorticoid use and glucocorticoid induced osteoporosis
- eating disorders
- HIV-infections and any malignancy including plasmacytosis and lymphoma.
Exclusion
Key Trial Info
Start Date :
August 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 1 2023
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04018287
Start Date
August 1 2017
End Date
June 1 2023
Last Update
January 26 2023
Active Locations (1)
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1
Medical University Vienna; St. Vincent Hospital
Vienna, Austria, 1060