Status:
ACTIVE_NOT_RECRUITING
Task Shifting to Treat Depression and HIV Medication Nonadherence in Low Resource Settings
Lead Sponsor:
King's College London
Collaborating Sponsors:
Massachusetts General Hospital
University of Zimbabwe College of Health Sciences
Conditions:
HIV Infections
Depression
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
A hybrid effectiveness-efficacy trial to evaluate a stepped care task shifted intervention to treat depression and HIV medication nonadherence in low resource settings in rural Zimbabwe.
Detailed Description
Depression is commonly co-morbid with HIV infection in Zimbabwe and is consistently associated with worse adherence to antiretroviral therapy (ART). A task-shifted intervention for depression and ART ...
Eligibility Criteria
Inclusion
- Initiated on ART for at least 6 months
- Clinically significant depression symptoms scoring \>/= 10 on the Patient Health Questionnaire-9
- Viral non-suppression in past two months per local clinic standard (VL \> 1000 copies/mL)
- Able to provide informed consent
- If prescribed antidepressants, on stable regimen for at least 2 months
Exclusion
- Unable to provide informed consent
- Active major mental illness (e.g. untreated psychosis or mania, actively suicidal), major untreated or undertreated mental illness or advanced physical disease or severe cognitive impairment assessed using the psychosis module of the MINI, the PHQ-9, and the International HIV dementia Scale which would interfere with engagement in PST-AD
- Has ever received PST or CBT for depression
- Less than 18 years of age
Key Trial Info
Start Date :
July 12 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2025
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT04018391
Start Date
July 12 2019
End Date
March 31 2025
Last Update
June 26 2024
Active Locations (1)
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1
Marondera Provincial Hospital
Marondera, Mashonaland East Province, Zimbabwe