Status:
COMPLETED
How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)
Lead Sponsor:
Endeavor Health
Conditions:
Knee Osteoarthritis
Total Knee Arthroplasty (TKA)
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of the study is to gain a better understanding of how genetic variations can affect pain experience and the need and type of pain control medication after a total knee replacement.
Detailed Description
The purpose of the study is to gain a better understanding of how genetic variations can affect pain experience and the need and type of pain control medication after a total knee replacement. People ...
Eligibility Criteria
Inclusion
- Age 18 or older
- Unilateral primary Total Knee Arthroscopy (TKA)
- Knee Osteoarthritis
- Planned discharge to home
Exclusion
- Unicompartmental Total Knee Arthroscopy (TKA)
- Revision Total Knee Arthroscopy (TKA)
- Knee flexion contracture \> 15°
- Axial deformity \> 15°
- Previous or current chronic narcotic use for pain \> 3 months
- Previous or current substance abuse
- Any chronic pain condition
- Any dementia or cognitive disorder
- Discharge to Skilled Nursing Facility
- Rheumatoid arthritis
- Potential difficulty completing daily pain scores and medication use
- Previous NorthShore genotyping
- Currently taking CYP2D6 inhibitors (list in appendix)
- Currently taking CYP2D6 inducers (list in appendix)
Key Trial Info
Start Date :
April 11 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
375 Patients enrolled
Trial Details
Trial ID
NCT04020471
Start Date
April 11 2019
End Date
December 31 2022
Last Update
April 27 2023
Active Locations (1)
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1
NorthShore University HealthSystem
Skokie, Illinois, United States, 60076