Status:
COMPLETED
Observe Alternating Hemiplegia of Childhood (OBSERV-AHC) Study
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Alternating Hemiplegia
Eligibility:
All Genders
Brief Summary
Alternating Hemiplegia of Childhood (AHC) is a rare and serious disease that is in need of effective, and hopefully even curative, therapies. Afflicted patients suffer from severe paralyzing crises, o...
Eligibility Criteria
Inclusion
- \- Patients who fit the Aicardi Alternating Hemiplegia of Childhood clinical criteria of any age. The Aicardi Criteria are six :
- Paroxysmal hemiplegia episodes.
- Bilateral hemiplegia or quadriplegia episodes.
- Other paroxysmal manifestations, such as abnormal eye movements, nystagmus, strabismus, ataxia, dystonia, choreoathetosis, tonic spells, or autonomic disturbances.
- Evidence of permanent neurological dysfunction, which can manifest as cognitive impairment, developmental delay, and/or persistent motor deficits such as spastic diplegia/quadriplegia, hypotonia, ataxia, choreoathetosis, or dystonia.
- Sleep relieves symptoms, although attacks may resume soon after awakening.
- First signs of dysfunction occur prior to the age of 18 months.
Exclusion
- Patients who do not have a mutation of the ATP1A3 gene and having only some of the above criteria
- Patients and / or their parents / legal guardian having provided their opposition to the study.
- Incapacity of patient / parent or other referent adult to participate in the prospective phase of observation of different paroxysmal events of the disease and in the scoring of the Vineland II adaptive behavior scales.
- Diagnosis of another disease, which could explain the presence of symptoms mentioned in the criteria of Aicardi.
Key Trial Info
Start Date :
October 28 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 17 2022
Estimated Enrollment :
34 Patients enrolled
Trial Details
Trial ID
NCT04020848
Start Date
October 28 2019
End Date
November 17 2022
Last Update
January 12 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospices Civils de Lyon Department of Clinical Epileptology, Sleep Disorders and Functional Neurology in Children
Bron, France, 69500