Status:
WITHDRAWN
Improving 24-hour Blood Pressure in Obstructive Sleep Apnea
Lead Sponsor:
University of British Columbia
Collaborating Sponsors:
Heart and Stroke Foundation of Canada
Michael Smith Foundation for Health Research
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
18-65 years
Phase:
EARLY_PHASE1
Brief Summary
This study examines the combined effects of an angiotensin receptor blocker (ARB), antioxidant supplementation, and continuous positive airway pressure (CPAP) therapy on the lowering of 24-hour blood ...
Detailed Description
OSA is a sleep disorder characterized by repetitive collapses (apneas) or partial collapses (hypopneas) of the upper airway. These airway obstructions result in intermittent reductions in arterial oxy...
Eligibility Criteria
Inclusion
- Apnea/Hypopnea Index (AHI) greater than/equal to 15 events per hour of sleep
- No prior use of CPAP
- Body mass index less than 30kg/m2
- Does not take ARBs or angiotensin converting enzyme inhibitors for blood pressure control
- Females of childbearing potential on an effective or highly effective means of contraception
Exclusion
- Prescribed and/or taking the following medications: diuretics (including potassium-sparing diuretics), Digoxin, lithium salts, and/or nonsteroidal anti-inflammatory drugs
- Over the counter supplements that affect the cardiovascular system, such as fish oils, vitamins, or other antioxidants
- History of heart failure
- History of myocardial infarction
- History of coronary artery disease
- History of stroke
- History of diabetes mellitus
- History of impaired renal function
- History of chronic obstructive pulmonary disease
- History of asthma
- History of central sleep apnea
- Smoked within the past year
- Hypotensive (Systolic blood pressure (SBP) \<90 mmHg and diastolic blood pressure (DBP) \<60 mmHg)
- Females who do not have a means of contraception, are pregnant, planning to become pregnant, and/or are breast-feeding
Key Trial Info
Start Date :
May 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2026
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04021550
Start Date
May 1 2023
End Date
December 1 2026
Last Update
May 19 2023
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