Status:
TERMINATED
Autonomic Mechanisms of Sleep-dependent Memory Consolidation
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Center for Advancing Translational Sciences (NCATS)
Conditions:
Memory
Sleep
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
The goal of the proposed project is to identify the impact vagal activity during sleep for memory formation. Nearly 100 years of research contends that sleep plays a critical role in memory consolidat...
Detailed Description
Poor sleep is associated with significant cognitive health decline. Recently, sleep disturbances have emerged as notable predictive and exacerbating factors in the onset and development of neurodegene...
Eligibility Criteria
Inclusion
- Healthy, adult volunteers between the ages of 18-64.
- English speaking
- Self-reported napping
Exclusion
- Aged greater than 64 years
- Lack of adherence to sleep/wake schedule of at least 7 hours a night for 5-days prior to study and during study timeline.
- Body mass index of 35 or above
- Presence of any clinical sleep disorder, including insomnia and obstructive sleep apnea (OSA)
- Presence of medical or psychiatric condition that is likely to affect sleep/wake function or cardiovascular functioning, including doctor diagnosed arrhythmia, bradycardia, hypertension, congestive heart failure, major depression, bipolar disorder, post-traumatic stress disorder.
- Medication use that is likely to affect sleep/wake function or cardiovascular functioning, including antidepressants, anxiolytic or soporific medication, and beta-blockers.
- Pregnancy
- Epilepsy
- head trauma
- alcoholism
- migraines
- metal pieces in the body (may confound tVNS delivery)
- history of substance abuse
Key Trial Info
Start Date :
October 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2020
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT04021797
Start Date
October 15 2019
End Date
March 15 2020
Last Update
May 28 2021
Active Locations (1)
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1
Langley Porter Psychiatric Institute
San Francisco, California, United States, 94143