Status:
COMPLETED
The Role of Endothelial Dysfunction in Adult Polycystic Kidney Disease
Lead Sponsor:
Sheffield Teaching Hospitals NHS Foundation Trust
Collaborating Sponsors:
University of Sheffield
Conditions:
Polycystic Kidney, Autosomal Dominant
Eligibility:
All Genders
18-50 years
Brief Summary
This pilot study will compare endothelial function in patients with ADPKD with matched healthy volunteers and normotensive chronic kidney disease stage 1 \& 2 patients. Patients will undergo a single ...
Detailed Description
Following recruitment we will record the following baseline demographics; age, gender, smoking status, body mass index, medical history. Participants will undergo a noninvasive vascular assessment, v...
Eligibility Criteria
Inclusion
- Age \>18yrs, \<50yrs
- Able to understand spoken/written English sufficiently to give informed consent and to take part in clinical assessment
- Clinical diagnosis of ADPKD
- eGFR \>60ml/min/1.73m2
Exclusion
- No history of cardiovascular disease or hypertension
- Not diabetic
- Not smoking
- Not breastfeeding
- Not pregnant
- Not taking any regular medication (except oral contraceptives)
- No musculoskeletal conditions contraindicating inflation of a blood pressure cuff to suprasystolic pressures around the forearm (as part of EndoPAT measurements)
- Not morbidly obese: BMI\<35 (May contribute to endothelial dysfunction)
- eGFR \<60ml/min/1.73m2
Key Trial Info
Start Date :
July 25 2011
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04023214
Start Date
July 25 2011
End Date
December 31 2018
Last Update
July 17 2019
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