Status:
UNKNOWN
Positive End-expiratory Pressure Effects to Predict Fluid Responsiveness
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Mechanical Ventilation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Volume expansion is one of the main treatments for shock. A test to predict the effectiveness of volume expansion prior to administration would avoid the need for excess treatment if it proves to be u...
Detailed Description
Volume expansion is one of the main treatments for shock, with the goal of increasing cardiac preload and, consequently, cardiac output. However, this increase only occurs if there is a preload-depend...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Coverage by a health insurance scheme
- Patient under mechanical invasive ventilation (tracheal intubation)
- PEEP level ≥10 cmH2O
- Cardiac flow monitoring device in place by the PiCCO2 system (Pulsion Medical Systems, Feldkirch, Germany).
- Decision by the doctors in charge of carrying out a passive leg raising test and / or a volume expansion
Exclusion
- Pregnancy
- Participation in another interventional study
- Patients under the protection of justice
- Thoracic drainage (preventing PEP changes from inducing intrathoracic and transpulmonary pressure changes from their hemodynamic effects).
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2020
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT04023786
Start Date
October 1 2019
End Date
November 1 2020
Last Update
July 18 2019
Active Locations (1)
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1
Dr Alexandra Beurton
Le Kremlin-Bicêtre, Val De Marne, France