Status:
UNKNOWN
A Genetic Family Cohort Study of Bipolar Disorder in Chinese Han Population
Lead Sponsor:
Shanghai Mental Health Center
Conditions:
Bipolar Disorder
Eligibility:
All Genders
15+ years
Brief Summary
This study intends to find out the pathogenic genes of bipolar disorder by collecting the two-phase family of Chinese Han population with the large sample using a family cohort study design, combined ...
Detailed Description
Bipolar disorder (BD) is a serious, complex, family-grafting mental illness. Studies have shown that genetic factors may be the dominant factor in the pathogenesis of bipolar disorder, thus, it is wor...
Eligibility Criteria
Inclusion
- BD patients from BD family:
- Meets the diagnostic criteria of BD in DSM-IV-TR, does not limit subtypes and current disease status;
- age ≥ 15 years old;
- Han nationality;
- There are enough audition levels to complete the necessary examinations for the study;
- Understand the research content and sign the informed consent form. If the patient is unable to sign the informed consent form due to the young age, senior age, low education level or other reasons, they can be signed by their relatives or signed by their guardian.
- Healthy menbers from BD family:
- age ≥ 15 years old;
- Han nationality;
- biological parents or compatriots of the proband, cousins;
- There are enough audition levels to complete the necessary examinations for the study;
- Understand the research content and sign the informed consent form. If the patient is unable to sign the informed consent form due to the young age, senior age, low education level or other reasons, they can be signed by their relatives or signed by their guardian.
- Healthy control enrollment criteria without family history:
- age ≥ 15 years old;
- Han nationality;
- gender matches the patient group in the family;
- There are enough audition levels to complete the necessary examinations for the study;
- Understand the research content and sign the informed consent form. If the patient is unable to sign the informed consent form due to his or her age, advanced age, low education level or other reasons, he or she may be entrusted to sign by his or her relatives or signed by his guardian;
Exclusion
- BD patients from BD family:
- There is a DSM-IV-TR axis II disease (mental retardation, etc.) that significantly affects the patient's current state of mind;
- There are serious physical diseases, it is difficult to complete the necessary examinations, including history of brain trauma or cerebrovascular disease, severe cirrhosis, acute and chronic failure, severe diabetes, aplastic anemia, moderate to severe malnutrition and other serious nerves, heart, Physical diseases such as liver, kidney, endocrine, and blood system or diseases that may interfere with the test evaluation (the abnormal index is more than 2 times higher than the normal value).
- Healthy menbers from BD family and healthy control enrollment criteria without family history::
- with a mental disorder that meets the diagnostic criteria for DSM-IV-TR axis I or who have suspected psychosis but do not meet the diagnostic criteria;
- There are DSM-IV-TR axis II diseases (mental retardation, etc.) that significantly affect the patient's current mental state;
- There are serious physical illnesses, and it is difficult to complete the necessary examinations.
Key Trial Info
Start Date :
March 28 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
2520 Patients enrolled
Trial Details
Trial ID
NCT04024553
Start Date
March 28 2019
End Date
December 31 2022
Last Update
July 18 2019
Active Locations (1)
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1
Shanghai Mental Health Center
Shanghai, Shanghai Municipality, China, 200030