Status:
RECRUITING
Phenotyping Genetic Risk for Type 2 Diabetes
Lead Sponsor:
University of Pennsylvania
Conditions:
Diabetes Mellitus, Type 2
Genetics
Eligibility:
All Genders
10-70 years
Phase:
NA
Brief Summary
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low gen...
Detailed Description
The study team will recruit individuals based on genetic risk score for type 2 diabetes from the biobank populations who have agreed to be recontacted for future research. Each participant will underg...
Eligibility Criteria
Inclusion
- Age 10-70 years
- Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
- Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
Exclusion
- prior diagnosis of type 1, type 2, or secondary diabetes
- use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
- acute illness that may impact insulin and glucose dynamics
- pregnancy
- hypothalamic obesity or related genetic disorder of metabolism
- recent systemic chemotherapy use
- gastrointestinal impairment or surgery that may impact absorption
- anemia
- major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
- inability to comply with study protocol
Key Trial Info
Start Date :
June 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04024631
Start Date
June 17 2019
End Date
June 30 2026
Last Update
September 10 2025
Active Locations (2)
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1
Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
2
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104