Status:
COMPLETED
High Intensity Interval Training in Endometrial Cancer
Lead Sponsor:
UNC Lineberger Comprehensive Cancer Center
Collaborating Sponsors:
National Cancer Institute (NCI)
Conditions:
Endometrial Cancer
Eligibility:
FEMALE
18-75 years
Phase:
NA
Brief Summary
This interventional trial recruits women with endometrial cancer to participate in high intensity interval training (HIIT) prior to their standard of care surgery. The study will evaluate tissue and b...
Detailed Description
Primary Objectives: 1\. Determine the anti-proliferative effect of HIIT on the endometrium of women with endometrial cancer 2. Participants will undergo baseline testing, be taught how to perform per...
Eligibility Criteria
Inclusion
- Patients with a diagnosis of endometrial cancer who are to undergo hysterectomy and staging
- Between 40-75 years old
- Body mass index of 30-50 kg/m2
- Endometrioid histology endometrial cancer
- Presumed clinically early stage disease (disease confined to uterus only)
- Have access to a Smart Phone
- Have access to email
- Agree to visit the exercise and sport science laboratory within 2 days of SOC visit for baseline testing if enrollment procedures cannot be done on the same day.
- Agree to visit clinic 2 (+/-2wks) weeks after surgery for SOC follow-up and post surgery visit, or willing to return to exercise and sport science laboratory 2 (+/-2wks) weeks post-surgery
Exclusion
- Meets American College of Sports Medicine Guidelines for physical activity (150 minutes / week)
- Currently doing HIIT
- Hospitalization for a stroke, heart attack, or heart failure, or had surgery for blocked arteries in the past 3 months
- Active diagnosis of psychosis or current uncontrolled substance abuse disorder
- Insulin-dependent diabetes
- Currently in another EC intervention
- Severe dementia or other memory loss condition
- Severe mental health disorder
- Severely impaired hearing or speech
- Inability to speak English
- Musculoskeletal or neuromuscular condition that limits physical activity Any condition, in the opinion of the investigators, which would prohibit safe participation.
Key Trial Info
Start Date :
September 23 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 8 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04025229
Start Date
September 23 2019
End Date
September 8 2024
Last Update
October 15 2025
Active Locations (1)
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1
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina, United States, 27599