Status:
UNKNOWN
Pathophysiology of Hypoventilation in Obesity and Effects of Bariatric Intervention
Lead Sponsor:
Guy's and St Thomas' NHS Foundation Trust
Conditions:
Obesity Hypoventilation Syndrome (OHS)
Eligibility:
All Genders
18-80 years
Brief Summary
Breathing is impacted by obesity. Early changes are characterised by significant breathing abnormalities during sleep (a condition called sleep disordered breathing, the most common of which is obstru...
Eligibility Criteria
Inclusion
- Patients 18 years or older
- BMI \> 40
- Patients with significant sleep disordered breathing requiring treatment
- Patient is being assessed for bariatric surgery for either gastric sleeve or gastric bypass surgery
Exclusion
- Patients with decompensated hypercapnic respiratory failure (pH\< 7.3)
- Chronic hypercapnic respiratory failure due to a cause other than obesity such as neuromuscular, chest wall or airway disease
- Unstable cardiac disease including coronary artery disease and heart failure
- Significant co-morbid psychiatric disease requiring anti-psychotic medications
- Chronic pain syndrome on high dose opioid medications
- Treatment for drug or alcohol addiction
- Cognitive impairment that would prevent informed consent
- Pregnancy
- Need for long-term renal replacement therapy
- Patients who undergo bariatric intervention with gastric balloon or gastric band.
Key Trial Info
Start Date :
June 20 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04025528
Start Date
June 20 2019
End Date
July 1 2024
Last Update
March 23 2023
Active Locations (1)
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1
Guy's and St Thomas' NHS Trust
London, United Kingdom, SE17EH