Status:
COMPLETED
Acute Effects of the Two Alternative Sweeteners D-allulose and Erythritol on Metabolism
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Physiological Satiation Mechanisms
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The aim of this project is to investigate the effect of intragastric (ig) D-allulose on metabolic parameters in general and to investigate the effect of sweet taste receptor blockade on GI hormone res...
Detailed Description
Erythritol (natural non-caloric sweetener) could be an ideal candidate substitute for sugar as it may reduce caloric intake without compensatory overeating or earlier return of hunger. Moreover, it ma...
Eligibility Criteria
Inclusion
- Healthy normal weight subjects with a body-mass index of 19.0-24.9
- Normal eating habits (no diets; no dietary changes)
- Age 18-55 years
- Stable body weight for at least three months
- Informed Consent as documented by signature (Appendix Informed Consent Form)
Exclusion
- Pre-existing consumption of erythritol or D-allulose on a regular basis (usage of erythritol or D-allulose as sugar replacement; in contrast, erythritol-containing toothpaste is allowed)
- Substance abuse
- Regular intake of medications, except anticonceptives
- Chronic or clinically relevant acute infections
- Pregnancy: although no contraindication, pregnancy might influence metabolic state. Women who are pregnant or have the intention to become pregnant during the course of the study are excluded. In female participants a urine pregnancy test is carried out upon screening.
- Participation in another study with investigational drug within the 30 days preceding and during the present study.
Key Trial Info
Start Date :
September 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2020
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT04027283
Start Date
September 1 2019
End Date
September 1 2020
Last Update
September 29 2020
Active Locations (1)
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1
St. Claraspital
Basel, Switzerland, 4002