Status:
UNKNOWN
Functional MRI-based Assessment of Terlipressin vs. Octreotide on Renal Function in Cirrhotic Patients With Acute Variceal Bleeding (CHESS1903)
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Collaborating Sponsors:
LanZhou University
Zhongda Hospital
Conditions:
Renal Function Disorder
Acute Variceal Bleeding
Eligibility:
All Genders
18-70 years
Phase:
PHASE4
Brief Summary
Acute variceal bleeding is one of the critical complications in patients with cirrhosis. Due to remarkable improvements in diagnostic and therapeutic modalities such as vasoactive agents, endoscopic t...
Detailed Description
Gastroesophageal varices, the most relevant portal-system collaterals, and acute variceal bleeding are critical complications that result directly from portal hypertension in patients with cirrhosis. ...
Eligibility Criteria
Inclusion
- clinically and/or pathologically diagnosed cirrhosis
- with a clinical history of acute variceal bleeding (melena, hematemesis etc.) assessed as Child-Pugh class B or C
- voluntarily participated in the study and able to provide written informed consent and able to understand and willing to comply with the requirements of the study
Exclusion
- pregnant or lactating woman
- diagnosed or suspected malignancy (hepatocellular carcinoma, cholangiocarcinoma etc.)
- with mental disease and unable to comply with MRI examination
- with contraindications of terlipressin and octreotide
- with other conditions judged inadequate for participation by the investigators.
Key Trial Info
Start Date :
July 16 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 15 2022
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04028323
Start Date
July 16 2019
End Date
October 15 2022
Last Update
August 17 2021
Active Locations (10)
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1
The Second Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
2
The First Hospital of Lanzhou University
Lanzhou, Gansu, China
3
Guangdong Second Provincial General Hospital
Guangzhou, Guangdong, China
4
Nanfang Hospital of Southern Medical University
Guangzhou, Guangdong, China