Status:
TERMINATED
The Strategy of "Pulmonary Opening by Titration of Positive End-expiratory Pressure" Means of a Pulmonary Recruitment Maneuver in Patients With Acute Respiratory Distress Syndrome: for Which Patients?
Lead Sponsor:
Centre Hospitalier de Lens
Conditions:
Respiratory Distress Syndrome, Adult
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Pulmonary recruitment maneuvers open these lung areas and appropriate adjustment of positive expiratory pressure (PEP) helps to stabilize recruitment and reduce the stress associated with alveolar ope...
Detailed Description
It will be a prospective interventional study in resuscitation patients with severe or moderate ARDS. This study will be multicentric between the University Hospital of Amiens and intensive care of Le...
Eligibility Criteria
Inclusion
- Will be included in the study, patients:
- Major patient (age ≥18 years)
- Controlled assisted ventilation, sedation and curarization adapted to the respirator.
- Within the first 72 hours of an ARDS (PaO2 / FiO2 ≤ 200 mmHg, FiO2 ≥ 60% and PEEP of ≥5 cmH20) (as recommended by the Berlin criteria)
- Decision of intensivist in charge of the patient to put an oesophageal probe
- After hemodynamic optimization (evaluation of the preload dependence and need for catecholamines)
- Decision of the intensivist in charge of the patient to perform a pulmonary opening test by titration of PEEP by means of a pulmonary recruitment test.
Exclusion
- Patients under the age of 18
- Pregnant women, women who are parturient or breastfeeding
- Patients with pulmonary broncho-emphysematous pathology or at risk of presenting it.
- Patients with a history of barotrauma or at risk of presenting it.
- Patients with a history of intracranial hypertension
- Patients with suspected or proven right ventricular dysfunction or uncontrolled hemodynamic instability after hemodynamic management.
- Patients with a contraindication to the placement of an oesophageal tube (esophageal surgery, severe esophageal pathology)
- Patients under guardianship or curatorship or deprived of liberty.
- Patients who are legally protected
- Patient not covered by French national health insurance
Key Trial Info
Start Date :
December 20 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 7 2021
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT04028336
Start Date
December 20 2019
End Date
January 7 2021
Last Update
March 4 2021
Active Locations (4)
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1
Chu Amiens
Amiens, France, 80054
2
CH Arras
Arras, France, 62000
3
Ch Germon Et Gauthier
Béthune, France, 62408
4
Hospital Dr Schaffner
Lens, France, 62307