Status:
TERMINATED
Diagnostic Interest of the IRAP Protein (Insulin Regulated Amino Peptidase) in Insulin Resistance
Lead Sponsor:
University Hospital, Grenoble
Conditions:
Insulin Resistance Syndrome
Eligibility:
All Genders
40-65 years
Phase:
NA
Brief Summary
There is currently no reliable, diagnostic tests of insulin resistance other than the hyperinsulinemic euglycemic clamp which, due to its constraints and cost, is reserved for research. The insulin-Re...
Detailed Description
This study consists of two visits, from three to fifteen days apart. Patients with different levels of insulin resistance will be enrolled in this study. The level of insulin resistance will be estim...
Eligibility Criteria
Inclusion
- Patient without known diabetes
- Abdominal perimeter greater than 80 cm for women and greater than 94 cm for men
- Patient affiliated to social security insurance or beneficiary of social security insurance.
- Signed consent
Exclusion
- Consumption of narcotic
- Medication that may interfere with glucose metabolism
- History of bariatric surgery
- Known acute or chronic renal insufficiency
- Hyperinsulinemic euglycemic clamp contraindication
- Contraindications with insulin, G20 glucose and Di-potassium phosphate
- Histories of coronary pathology
- History of heart rhythm disorders requiring chronic treatment
- Period of fast
- Pregnant women
Key Trial Info
Start Date :
September 14 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2022
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT04028895
Start Date
September 14 2020
End Date
June 30 2022
Last Update
August 11 2022
Active Locations (4)
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1
Service de Nutrition clinique et CRNH Auvergne
Clermont-Ferrand, France
2
Inserm CIC1406, clinical research center, Grenoble Alpes university hospital
Grenoble, France, 38043
3
CRNH Rhône-Alpes et Centre Hospitalier LYON Sud
Lyon, France, 69000
4
Endocrinologie-Diabétologie-Nutrition et CIC, CHU DE MONTPELLIER
Montpellier, France