Status:
UNKNOWN
Molecular Analysis of Diabetic Kidney Disease Biopsies
Lead Sponsor:
Unity Health Toronto
Collaborating Sponsors:
University of Ottawa
University of British Columbia
Conditions:
Diabetic Nephropathies
Kidney Disease, Chronic
Eligibility:
All Genders
18+ years
Brief Summary
Despite decades of research, the pathogenesis of human diabetic kidney disease remains largely unclear. Our goal is to use archived human kidney biopsy tissue from patients with and with diabetic neph...
Detailed Description
RESEARCH OBJECTIVES A. To identify differences in transcription profiles obtained from residual kidney tissue which was obtained for clinical purposes. B. To identify differences in transcription pro...
Eligibility Criteria
Inclusion
- Inclusion Criteria (diabetic kidney disease cases):
- history of type 1 or type 2 diabetes
- at least 1 archived native kidney biopsy that demonstrates either pure diabetic kidney disease or features of non-specific vascular disease, including glomerulosclerosis, non-inflammatory vascular disease,
- sufficient remaining archived kidney biopsy tissue for RNA sequencing (100 um thick tissue section) and histologic analysis (PAS and Masson Trichrome staining)
- Exclusion Criteria (diabetic kidney disease cases):
- less than 3 eGFR values post-biopsy
- latest recorded eGFR values less than 6 months post-biopsy
- Inclusion Criteria (healthy controls):
- \- at least 1 native kidney disease biopsy with no diagnostic abnormality
Exclusion
Key Trial Info
Start Date :
July 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT04029402
Start Date
July 1 2019
End Date
December 1 2025
Last Update
April 30 2021
Active Locations (4)
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1
University of British Columbia
Vancouver, British Columbia, Canada
2
University of Manitoba
Winnipeg, Manitoba, Canada
3
University of Ottawa
Ottawa, Ontario, Canada
4
St. Michael's Hospital
Toronto, Ontario, Canada, M5B 1W8