Status:
UNKNOWN
Multi-omics Study on Gut Microbiota in Critical Ill Patients After Cardiopulmonary Bypass
Lead Sponsor:
Peking Union Medical College Hospital
Conditions:
Sepsis
Cardiopulmonary Bypass
Eligibility:
All Genders
18-80 years
Brief Summary
Using metagenomics as well as metabolomics, the variation of the gut microbiota and host metabolite profiles of patient after undergoing CPB were explored.
Detailed Description
This protocol is designed as a prospective observational case-control study in patients who underwent cardiopulmonary bypass (CPB) due to cardiac surgery. 30 healthy persons were selected as control g...
Eligibility Criteria
Inclusion
- Patients will be admitted to ICU between 18 and 85 years of age who will undergo extracorporeal circulation during cardiac surgery and provided written informed consent will be enrolled as candidates of case group.
- Healthy volunteers will be enrolled as control group.
Exclusion
- Patients had a fever before surgery, regardless of the etiological evidence of infection;
- had anti-infective treatment before surgery;
- had gastrointestinal surgery which left the digestive system dysfunctional;
- had a history of CPB in 6 month;
- reject or abandon ICU therapeutic intervention.
Key Trial Info
Start Date :
August 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2019
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT04032938
Start Date
August 1 2018
End Date
December 31 2019
Last Update
July 29 2019
Active Locations (1)
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1
Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100730