Status:
RECRUITING
Repeated Oscillatory TMS Therapy of the Epileptogenic Cortical Area in Children With Focal CSWS
Lead Sponsor:
Children's Mercy Hospital Kansas City
Collaborating Sponsors:
The Methodist Hospital Research Institute
Cornell University
Conditions:
CSWS
Eligibility:
All Genders
3-21 years
Phase:
NA
Brief Summary
The investigators are investigating the effectiveness of a wearable multisite transcranial magnetic stimulation (mTMS) device that can deliver stimuli at multiple cortical sites simultaneously or sequ...
Detailed Description
Continuous Spike and Wave during Sleep (CSWS) is a rare neurological disease with an incidence of 0.2 - 0.5% of childhood epilepsy. It is often accompanied by comprehensive damage to brain function an...
Eligibility Criteria
Inclusion
- Patients between the ages of 3 and 21 years old,
- An electroclinical diagnosis of focal CSWS as defined by ILAE
- SWI of ≥ 85% in sleep on EEG's performed on previous or most recent EEG study.
- No change in antiepileptic drugs (AED) in last 2 week, or patients not on any AED
Exclusion
- Presence of metal implants or metallic devices in the head
- Any history of drug or alcohol abuse
- Presence of cardiac pacemaker
- Generalized CSWS
- All study patients will be enrolled for treatment with TMS to see if this modality of treatment has any effect on SWI on CSWS.
- Additional exclusions are:
- Adults unable to consent
- Pregnant women
- Prisoners
- Wards of the state
- Non English speaking subjects and families
Key Trial Info
Start Date :
August 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04034030
Start Date
August 1 2019
End Date
July 31 2026
Last Update
May 8 2025
Active Locations (1)
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1
Children's Mercy Hospital
Overland Park, Kansas, United States, 66211