Status:
UNKNOWN
Parecoxib as an Adjuvant to Scalp Nerve Blocks for Relief of Post-craniotomy Pain
Lead Sponsor:
Beijing Tiantan Hospital
Conditions:
Pain, Postoperative
Neurosurgery
Eligibility:
All Genders
18-64 years
Phase:
PHASE4
Brief Summary
Pain is common for the first 2 days after major craniotomy. Inadequate analgesia induced sympathetically mediated hypertension may lead to an increased risk for post-operative complications, such as a...
Eligibility Criteria
Inclusion
- Patients aged 18 to 64 years
- American Society of Anesthesiologists (ASA) physical status of I, II and III
- Preoperative Glasgow Coma Scale (GCS) score of 15/15
- Scheduled for elective craniotomy under general anesthesia
Exclusion
- Patients with chronic headache or chronic pain syndrome for any reason
- Patients with psychiatric disorders, uncontrolled epilepsy, coagulopathy, infection around puncture point
- Inability to understand and incapacity to use the pain scales before surgery
- Pregnancy or at breastfeeding;
- Participation in another intervention trial that interferes with the intervention or outcome of this trial
- History of allergies to any of the study drugs
- Refusal to participate or unable to acquire informed consent provided by the patients and/or legal guardian
- Having their first craniotomy surgery with an occipital bone defect
- Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, use of any painkiller within 24 hours before surgery
- Extreme body mass index (BMI) (\< 15 or \> 35);
Key Trial Info
Start Date :
October 12 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT04034836
Start Date
October 12 2019
End Date
December 31 2021
Last Update
June 16 2020
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, Beijing Municipality, China, 100070